Elucidating the causal triad of cardiovascular disease, cancer, and lipid traits: a bidirectional Mendelian randomization study with genetic mediation analysis
This study explored the pairwise causal relationships among lipid, CVD, and cancer from a genetic perspective. However, the identified inverse causal associations should be interpreted as effects at the genetic level, rather than as evidence supporting CVD as a direct preventive strategy against cancer in clinical practice. Nonetheless, these findings inspire further investigation into novel biological mechanisms linking CVD and cancer, with the potential to identify new anticancer strategies.
Authors
- Linda M. Liao (ORCID: https://orcid.org/0000-0002-1923-5294)
- Ai‐Ming Zeng
- Jiaqi Hu (ORCID: https://orcid.org/0000-0003-1114-2357)
- Jiansheng Chen (ORCID: https://orcid.org/0000-0002-2040-7938)
- Weijie Wu (ORCID: https://orcid.org/0000-0002-2106-4930)
- Yuheng Jiao
- Yunzhe Yu
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Shanghai East Hospital (CN)
- Fujian Provincial Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1007/s12672-025-03736-0
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fujian Medical University
- Fujian Provincial Hospital