Term birth and levothyroxine dosage are significant factors associated with permanent congenital hypothyroidism: experience from a medical center in Taiwan
Nearly half of the patients required lifelong levothyroxine supplements under the current newborn screening program. Permanent congenital hypothyroidism patients were more likely term-born, showed delayed TSH normalization, had higher TSH levels, and required higher levothyroxine doses during follow-up. The best cut-off level to discriminate permanent from transient congenital hypothyroidism was 2.5 and 1.8 µg/kg/day at the age of 2 and 3 years, respectively.
Authors
- Wei‐Hsin Ting (ORCID: https://orcid.org/0000-0003-1849-3993)
- Yi-Hsin Wu (ORCID: https://orcid.org/0000-0002-6618-5699)
- Yann‐Jinn Lee (ORCID: https://orcid.org/0000-0003-1802-9824)
- Chin-Hui Tseng
- Luting Wang (ORCID: https://orcid.org/0009-0006-3294-7006)
- Yi‐Lei Wu
- Chao‐Hsu Lin
- Chi‐Yu Huang
- Yu-En Kao
Institutions
- National Yang Ming Chiao Tung University (TW)
- Mackay Memorial Hospital (TW)
- Mackay Medical University (TW)
- Zhongshan Hospital (CN)
- Changhua Christian Hospital (TW)
- Memorial Hospital (US)
Publication Details
- Journal
- BMC Pediatrics
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12887-025-06199-y
- Primary Topic
- Thyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00