Development and validation of predictive models combining cell-Free DNA motifs and protein biomarkers for early detection of esophageal squamous cell carcinoma and precancerous lesion
The motif-protein model may serve as an effective tool for the early diagnosis of esophageal lesions. Our findings underscore the clinical potential of the multi-omics liquid biopsy test as a non-invasive method for detecting early esophageal lesions.
Authors
- Yumeng Liu (ORCID: https://orcid.org/0000-0002-5055-2861)
- Jiangtao Chu
- Xudong Liu (ORCID: https://orcid.org/0000-0002-1406-6452)
- Yong Liu (ORCID: https://orcid.org/0000-0002-4048-5837)
- Siyao Liu (ORCID: https://orcid.org/0009-0009-7131-2187)
- Ke Yan (ORCID: https://orcid.org/0000-0001-6314-0762)
- Liu Ma
- Shun He (ORCID: https://orcid.org/0000-0002-3472-9532)
- Zhengqi Li (ORCID: https://orcid.org/0000-0002-1351-8410)
- Guiqi Wang (ORCID: https://orcid.org/0000-0003-4544-6949)
- Yueming Zhang (ORCID: https://orcid.org/0000-0003-3625-3280)
- Hoi-loi Ng
- Lizhou Dou
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- National Cancer Center (US)
- Shaanxi Provincial People's Hospital (CN)
Publication Details
- Journal
- Biomarker Research
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s40364-025-00840-9
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Academy of Medical Sciences
- Cancer Foundation of China