Clustered cardiometabolic risk in pregnancy and dysmenorrhea in offspring: Results from a prospective birth cohort study
No evidence was found of maternal CCMR and dysmenorrhea in offspring. However, higher maternal pre-pregnancy BMI increased dysmenorrhea risk, partly mediated by heavier BMI and earlier pubertal timing in offspring. These findings align with the hypothesis of a possible intrauterine origin of menstrual disorders and highlight the importance of early life factors in dysmenorrhea research.
Authors
- Tanja G. M. Vrijkotte (ORCID: https://orcid.org/0000-0003-3641-4048)
- Nikol Shkarpa (ORCID: https://orcid.org/0000-0002-0624-6314)
- Siyu Zhou (ORCID: https://orcid.org/0000-0001-5583-4545)
- Martijn J.J. Finken (ORCID: https://orcid.org/0000-0002-6589-9788)
- Marcel Twickler (ORCID: https://orcid.org/0000-0001-8738-207X)
- Catherine B. Brouwer
- E. van den Boogaard
Institutions
- University of Antwerp (BE)
- Emma Kinderziekenhuis (NL)
- Province of Antwerp (BE)
- Amsterdam University Medical Centers (NL)
- University of Amsterdam (NL)
Publication Details
- Journal
- European Journal of Clinical Investigation
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1111/eci.70134
- Primary Topic
- Menstrual Health and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- China Scholarship Council