Construction of a lipid metabolism-based prognostic gene signature in cervical squamous cell carcinoma and validation of LIPG’s oncogenic role
The LMPS was a valuable prognostic tool and was correlated with the TME and drug sensitivity. LIPG was a key regulator of lipid metabolism and facilitated CSCC development by hydrolyzing PC into lysophosphatidylcholine (LPC) and activating the MAPK-p38 signaling pathway. These findings may highlight the potential of targeting lipid metabolism for therapeutic intervention in CSCC.
Authors
- Fanghua Chen (ORCID: https://orcid.org/0009-0006-6441-1986)
- Junjun Qiu (ORCID: https://orcid.org/0000-0002-2063-2684)
- Gaigai Bai
- Keqin Hua (ORCID: https://orcid.org/0000-0002-4546-5229)
Institutions
- Obstetrics and Gynecology Hospital of Fudan University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12935-025-03991-9
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China