Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity
Among over 300 proteins investigated by NULISA, GFAP was the main biomarker significantly associated with future PIRA risk in our cohort.
Authors
- Jan Lycke (ORCID: https://orcid.org/0000-0002-7891-8466)
- Sabine Schädelin (ORCID: https://orcid.org/0000-0002-1150-0962)
- David Hunt (ORCID: https://orcid.org/0000-0003-4230-0207)
- Eline A.J. Willemse (ORCID: https://orcid.org/0000-0001-9140-4243)
- Patrice H. Lalive (ORCID: https://orcid.org/0000-0003-0607-5778)
- Ahmed Abdelhak (ORCID: https://orcid.org/0000-0001-9731-4169)
- Claudio Gobbi (ORCID: https://orcid.org/0000-0002-7554-0664)
- Patrick Roth (ORCID: https://orcid.org/0000-0003-3897-214X)
- Jens Kühle (ORCID: https://orcid.org/0000-0002-6963-8892)
- Sofia Sandgren (ORCID: https://orcid.org/0000-0001-6206-3339)
- Ludwig Kappos (ORCID: https://orcid.org/0000-0003-4175-5509)
- Robert Hoepner (ORCID: https://orcid.org/0000-0002-0115-7021)
- Amanda Heslegrave (ORCID: https://orcid.org/0000-0002-7290-6405)
- Maximilian Einsiedler (ORCID: https://orcid.org/0000-0002-0786-2872)
- David Leppert (ORCID: https://orcid.org/0000-0001-6172-801X)
- Pascal Benkert (ORCID: https://orcid.org/0000-0001-6525-8174)
- Caroline Pot (ORCID: https://orcid.org/0000-0002-1146-3129)
- Aleksandra Maleska Maceski (ORCID: https://orcid.org/0000-0002-1916-5927)
- Johanna Oechtering (ORCID: https://orcid.org/0000-0001-5359-7961)
- Cristina Granziera (ORCID: https://orcid.org/0000-0002-4917-8761)
- Manuel Comabella (ORCID: https://orcid.org/0000-0002-2373-6657)
- Lutz Achtnichts (ORCID: https://orcid.org/0000-0002-3713-9570)
- Tobias Derfuss (ORCID: https://orcid.org/0000-0001-8431-8769)
- Stefanie Müller
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0002-4671-6763)
Institutions
- University of Geneva (CH)
- University of Bern (CH)
- Universitat Autònoma de Barcelona (ES)
- University of California, San Francisco (US)
- University of Basel (CH)
- University of Zurich (CH)
- University of St.Gallen (CH)
- University Hospital of Bern (CH)
- Sahlgrenska University Hospital (SE)
- University Hospital of Basel (CH)
- Laboratory for Biomedical Neurosciences (CH)
- Region Västra Götaland (SE)
- University Hospital of Zurich (CH)
- Vall d'Hebron Institut de Recerca (ES)
- University Hospital of Geneva (CH)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Kantonsspital Aarau (CH)
- University College London (GB)
- Università della Svizzera italiana (CH)
- Geneva College (US)
- University of Gothenburg (SE)
- University of Lausanne (CH)
- University of Edinburgh (GB)
Publication Details
- Journal
- Multiple Sclerosis Journal
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1177/13524585251375780
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00