Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity

Among over 300 proteins investigated by NULISA, GFAP was the main biomarker significantly associated with future PIRA risk in our cohort.

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Publication Details

Journal
Multiple Sclerosis Journal
Published
2025-10-14
DOI
https://doi.org/10.1177/13524585251375780
Primary Topic
RNA Interference and Gene Delivery
Type
article
Field-Weighted Citation Impact
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article

Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity

Jan Lycke, Sabine Schädelin, David Hunt, Eline A.J. Willemse et al.
Multiple Sclerosis Journal
RNA Interference and Gene Delivery
article

Biomarker discovery using NUcleic Acid-Linked Immuno-Sandwich Assay in multiple sclerosis patients experiencing progression independent of relapse activity

Jan Lycke, Sabine Schädelin, David Hunt, Eline A.J. Willemse, Patrice H. Lalive, Ahmed Abdelhak, Claudio Gobbi, Patrick Roth, Jens Kühle, Sofia Sandgren, Ludwig Kappos, Robert Hoepner, Amanda Heslegrave, Maximilian Einsiedler, David Leppert, Pascal Benkert, Caroline Pot, Aleksandra Maleska Maceski, Johanna Oechtering, Cristina Granziera, Manuel Comabella, Lutz Achtnichts, Tobias Derfuss, Stefanie Müller, Henrik Zetterberg
article en

Abstract

Among over 300 proteins investigated by NULISA, GFAP was the main biomarker significantly associated with future PIRA risk in our cohort.

Multiple Sclerosis JournalVol. 31(13)
University of Geneva (CH), University of Bern (CH), Universitat Autònoma de Barcelona (ES), University of California, San Francisco (US), University of Basel (CH), University of Zurich (CH), University of St.Gallen (CH), University Hospital of Bern (CH), Sahlgrenska University Hospital (SE), University Hospital of Basel (CH), Laboratory for Biomedical Neurosciences (CH), Region Västra Götaland (SE), University Hospital of Zurich (CH), Vall d'Hebron Institut de Recerca (ES), University Hospital of Geneva (CH), UK Dementia Research Institute (GB), National Hospital for Neurology and Neurosurgery (GB), Kantonsspital Aarau (CH), University College London (GB), Università della Svizzera italiana (CH), Geneva College (US), University of Gothenburg (SE), University of Lausanne (CH), University of Edinburgh (GB)
Openalex Percentile: Top 74%
RNA Interference and Gene Delivery
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