Interaction between embryo transfer timing (D3/D4) and duration of progesterone exposure (P3/P4) on live birth rate in hormone replacement therapy cycles of frozen embryo transfer
Frozen embryo transfer cycles prepared with hormone replacement demonstrate higher live birth rates when embryos are transferred on day 4 rather than day 3, regardless of whether progesterone exposure is 3 or 4 days. When embryo developmental stage is fixed (D3 or D4), varying the duration of progesterone exposure (3 vs 4 days) does not significantly influence clinical or perinatal outcomes.
Authors
- Chuangqi Chen (ORCID: https://orcid.org/0000-0003-0361-1301)
- Fang Wang (ORCID: https://orcid.org/0009-0009-7713-561X)
- Fenghua Liu (ORCID: https://orcid.org/0000-0002-3860-9466)
- Yujiang Wang (ORCID: https://orcid.org/0000-0002-6220-029X)
- Xiqian Zhang
- Lin Fan (ORCID: https://orcid.org/0009-0003-2210-6279)
- Haiying Zhu
- Hu Tan
Institutions
- Guangdong Province Women and Children Hospital (CN)
Publication Details
- Journal
- Reproductive Biology and Endocrinology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12958-025-01469-x
- Primary Topic
- Ovarian function and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangzhou Municipal Science and Technology Project