Novel Podocyte-Targeting Biomarkers in Membranous Nephropathy: Looking beyond PLA2R & THSD7A – A Systematic Review v1

Membranous Nephropathy is an autoimmune glomerular disease and is the most frequent cause of nephrotic syndrome among Caucasian adults. Following Anti-Phospholipase A2 Receptor (PLA2R) and Thrombospondin Type 1 Domain Containing 7A (THSD7A), new biomarkers of Membranous Nephropathy (MN) in adults, including Neural Epidermal growth factor-Like 1 (NELL-1), Exostosin 1/ Exostosin 2 (EXT1/ EXT2), Protocadherin7 (PCDH7), Transforming Growth Factor Beta Receptor 3 (TGFBR3) and Neural Cell Adhesion Molecule 1 (NCAM1), have been discovered. PubMed, Scopus, Web of Science and CENTRAL will be systematically searched until February 2025. Two reviewers will determine study eligibility according to the title and the abstract of the articles. The full-text publications of potentially relevant articles will be retrieved and rescreened by the same investigators. ROBINS-E tool will be used to evaluate quality of evidence and risk of bias in the included studies.