Neutrophil elastase promotes mucin secretion in airway epithelial cells through the MARCKS/ACK1/cortactin pathway
NE induces the phosphorylation of MARCKS, which subsequently facilitates the phosphorylation of ACK1. This cascade enhances the phosphorylation of cortactin, ultimately leading to increased mucus secretion. The MARCKS/ACK1/cortactin pathway is a potential therapeutic target for excessive mucus secretion induced by NE.
Authors
- Shaxi Ouyang (ORCID: https://orcid.org/0000-0003-2319-5640)
- Mingxin He (ORCID: https://orcid.org/0000-0001-8229-7925)
- Juliy M. Perelman (ORCID: https://orcid.org/0000-0002-9411-7474)
- Victor P. Кolosov (ORCID: https://orcid.org/0000-0002-8854-4752)
- Xiangdong Zhou (ORCID: https://orcid.org/0000-0002-5866-8682)
- Yanyan Li (ORCID: https://orcid.org/0000-0002-4583-1524)
- Qi Li (ORCID: https://orcid.org/0000-0003-2120-2261)
- Yan Liu (ORCID: https://orcid.org/0009-0000-0536-9454)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Far Eastern Scientific Centre of Physiology and Pathology of Respiration Russian Academy of Medical Sciences (RU)
- Peking University Shenzhen Hospital (CN)
- Hainan Medical University (CN)
Publication Details
- Journal
- Central European Journal of Immunology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.5114/ceji.2025.154158
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Shantou University
- National Natural Science Foundation of China
- Guangzhou University of Chinese Medicine
- Guangzhou University
- National Key Research and Development Program of China