Hippo pathway suppression reprograms TNFα-primed glioblastoma extracellular vesicles transcripts cargo to drive mesenchymal stem/stromal cells vasculogenic mimicry
By inhibiting the Hippo pathway and TNFα-induced pro-inflammatory cargo of GBM-derived EVs, our data support VT107 as a potential candidate to inhibit tumor-promoting processes involved in therapy resistance such as paracrine induction of MSC-mediated VM.
Authors
- Alain Zgheib
- Borhane Annabi (ORCID: https://orcid.org/0000-0002-5082-7183)
- Luc H. Boudreau (ORCID: https://orcid.org/0000-0002-3674-5026)
- Nicoletta Eliopoulos (ORCID: https://orcid.org/0000-0002-5172-8742)
- Angélique Sabaoth Konan
- Rosalie Zilinski
Institutions
- Université de Moncton (CA)
- Université du Québec à Montréal (CA)
- Jewish General Hospital (CA)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12964-025-02401-x
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université du Québec à Montréal
- Natural Sciences and Engineering Research Council of Canada