Estrogen improves sevoflurane-induced cognitive dysfunction by regulating synaptic zinc homeostasis
This study reveals that sevoflurane-induced cognitive dysfunction is closely associated with synaptic zinc imbalance. Estrogen exerts its neuroprotective effects by restoring synaptic zinc homeostasis. These findings provide insights into the pathophysiological mechanisms underlying anesthesia-related cognitive impairment and highlight the therapeutic potential of estrogen in perioperative neuroprotection.
Authors
- Yi Jiang (ORCID: https://orcid.org/0000-0003-0622-0699)
- Feixiang Li (ORCID: https://orcid.org/0000-0001-6919-5158)
- Yang Yu (ORCID: https://orcid.org/0000-0002-8303-8690)
- Dujuan Li
- Siwen Long (ORCID: https://orcid.org/0000-0003-3576-3123)
- Jun Zhang (ORCID: https://orcid.org/0000-0001-7886-6187)
- Tao Yang (ORCID: https://orcid.org/0000-0003-2364-4047)
- Yongyan Yang (ORCID: https://orcid.org/0000-0002-2189-2242)
- Bo Gong (ORCID: https://orcid.org/0000-0001-8013-4196)
Institutions
- Wannan Medical College (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s10020-025-01364-6
- Citations
- 1
- Primary Topic
- Anesthesia and Neurotoxicity Research
- Type
- article
- Field-Weighted Citation Impact
- 1.32
Funders
- National Natural Science Foundation of China
- Tianjin Medical University