The post-operative loading regimen influences the regenerative potential of a biomimetic osteochondral scaffold
Our study highlighted the importance of controlled mechanical loading in osteochondral scaffold development for cartilage repair. Partial load proved favorable for scaffold healing and integration, improving mobility and reducing limping in the animal model.
Authors
- A. Manunta (ORCID: https://orcid.org/0000-0003-2771-2190)
- Antonio Brunetti (ORCID: https://orcid.org/0000-0002-0116-1899)
- Maria Antonietta Evangelisti (ORCID: https://orcid.org/0000-0003-3071-8075)
- Umberto Cardinale (ORCID: https://orcid.org/0000-0001-9975-7940)
- Pietro Parisse (ORCID: https://orcid.org/0000-0002-7420-2778)
- Giuseppe Filardo (ORCID: https://orcid.org/0000-0002-8136-0977)
- Marco Pes (ORCID: https://orcid.org/0000-0002-2848-0283)
- Alessio Pulino (ORCID: https://orcid.org/0000-0002-5982-857X)
- Lucia Manunta
- Edoardo Fantinato
Institutions
- University of Sassari (IT)
- Royal London Hospital (GB)
- Istituto Officina dei Materiali (IT)
- Azienda Ospedaliero Universitaria di Sassari (IT)
- Università della Svizzera italiana (CH)
Publication Details
- Journal
- BioMedical Engineering OnLine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12938-025-01377-6
- Citations
- 2
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.34