Hypoxia-inducible factor 2α overexpression in podocytes ameliorates lipid metabolism disorders in diabetic kidney disease by inhibiting S1P
<b>Conclusion:</b> HIF-2α ameliorated lipid metabolism disorders and podocyte damage in DKD by downregulating S1P, providing a novel insight for HIF-2α against DKD.
Authors
- Huibin Nie
- Qimeng Wang (ORCID: https://orcid.org/0009-0003-3103-393X)
- Xue Yang (ORCID: https://orcid.org/0000-0002-1288-5569)
- Qingzhen Liu (ORCID: https://orcid.org/0000-0003-0426-1921)
- Mingming Wang (ORCID: https://orcid.org/0000-0003-0638-6357)
- Gang Liu (ORCID: https://orcid.org/0000-0003-1981-2634)
- Yinghui Wang (ORCID: https://orcid.org/0000-0002-8347-8194)
- Shan Li (ORCID: https://orcid.org/0000-0001-6477-3043)
Institutions
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
- Chengdu University (CN)
- CM Hospital (KR)
Publication Details
- Journal
- Renal Failure
- Published
- 2025-10-12
- DOI
- https://doi.org/10.1080/0886022x.2025.2568972
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00