Subpopulations in clinical samples of <i>M. tuberculosis</i> can give rise to rifampicin resistance and shed light on how resistance is acquired
Our results indicate that a substantial fraction of false negative calls in WGS-based rifampicin resistance prediction can be explained by masked resistant subpopulations. The genetic diversity within the heterogeneous samples is consistent with at least 28% of the rifampicin resistance arising from secondary infections.
Authors
- Philip W. Fowler (ORCID: https://orcid.org/0000-0003-0912-4483)
- Viktoria Brunner (ORCID: https://orcid.org/0000-0001-5167-9840)
Institutions
- University of Liverpool (GB)
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool (GB)
Publication Details
- Journal
- JAC-Antimicrobial Resistance
- Published
- 2025-09-03
- DOI
- https://doi.org/10.1093/jacamr/dlaf175
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- National Institute for Health Research Health Protection Research Unit
- National Institute for Health and Care Research
- Department of Health and Social Care
- University of Oxford
- Directorate for Biological Sciences
- NIHR Oxford Biomedical Research Centre