Neural Regulation of Urothelial Water Transport: Pelvic Nerve Stimulation Induces Aquaporin-2 and Vasopressin V1a Receptor Translocation in the Rat Urinary Bladder
Pelvic nerve stimulation may trigger the relocalization of AQP2 and AVP-V1a from the cytosol to the membrane in bladder urothelial cells. This suggests a novel neurophysiological mechanism for modulating bladder water transport, with potential implications for understanding bladder homeostasis and dysfunction suggesting a possible role in regulating bladder water permeability.
Authors
- Seong Hyeon Yu (ORCID: https://orcid.org/0000-0002-1761-2025)
- Do Gyeong Lim (ORCID: https://orcid.org/0000-0002-5955-0758)
- Ho Seok Chung (ORCID: https://orcid.org/0000-0002-8735-1684)
- Sun-Ouck Kim
Institutions
- Chonnam National University (KR)
- Chonnam National University Hospital (KR)
Publication Details
- Journal
- International Neurourology Journal
- Published
- 2025-09-26
- DOI
- https://doi.org/10.5213/inj.2550168.084
- Primary Topic
- Urinary Bladder and Prostate Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation
- Chonnam National University
- National Research Foundation of Korea
- Ministry of Education, Science and Technology