Andrographolide suppresses chondrosarcoma cell migration and invasion by inhibiting the PI3K/Akt/mTOR signaling pathway and activating autophagy
Therefore, Andro could reduce the migration and invasion of chondrosarcoma cells by modulating the PI3K/Akt/mTOR signaling pathway, alleviating autophagy inhibition, and subsequently promoting autophagic activity.
Authors
- Wan-Hao Zhang
- Liang Ouyang (ORCID: https://orcid.org/0000-0001-5537-8834)
- Shuo Yang (ORCID: https://orcid.org/0000-0001-8906-5289)
- Shuai Fan (ORCID: https://orcid.org/0000-0002-7385-1979)
- Chun-Fei Wu
- Peng Li (ORCID: https://orcid.org/0000-0002-4715-9989)
- Yong Lin
- Zu‐Jian Liang
- Xian‐Xing Zhong
Institutions
- Guangzhou University of Chinese Medicine (CN)
- The Third Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fonc.2025.1622666
- Primary Topic
- Andrographolide Research and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00