Optimization of gabapentin dosage in pediatric patients with renal impairment: a physiologically based pharmacokinetic modeling approach
PBPK models provide better guidance for GAB dosing in pediatric patients with varying RI degrees, laying a foundation for precision therapy. This study is a significant step in optimizing GAB treatment for this high-risk pediatric population.
Authors
- Chaozhuang Shen (ORCID: https://orcid.org/0000-0002-2263-2709)
- Yujie Yang (ORCID: https://orcid.org/0000-0001-6941-0380)
- Zhimin Li (ORCID: https://orcid.org/0000-0002-0360-3160)
- Xiaoli Qin (ORCID: https://orcid.org/0000-0003-2869-5660)
Institutions
- Sichuan University (CN)
- Third People's Hospital of Chengdu (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- Southwest Jiaotong University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-26
- DOI
- https://doi.org/10.3389/fphar.2025.1669990
- Primary Topic
- Pharmaceutical studies and practices
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui Medical University