Increased acid sphingomyelinase levels in saliva as oral mucositis severity predictors
Although there is currently limited evidence for the potential implementation of salivary biomarkers to assess their association with the severity of OM, the findings here show that determining ASM levels in the saliva of HNC patients before starting RT could be a promising method to predict OM risk.
Authors
- Diana Klein (ORCID: https://orcid.org/0000-0002-1770-443X)
- Elsa Beatriz Monroy Ordonez
- Verena Jendrossek (ORCID: https://orcid.org/0000-0003-1058-2107)
- M. Henke (ORCID: https://orcid.org/0000-0003-0673-3873)
- Andreas Thomsen (ORCID: https://orcid.org/0000-0002-0163-8677)
- Anca-Ligia Grosu (ORCID: https://orcid.org/0000-0003-2255-2255)
- Kristian Unger (ORCID: https://orcid.org/0000-0002-0374-2320)
- Henning Schäfer (ORCID: https://orcid.org/0000-0002-5948-5095)
- Tanja Sprave (ORCID: https://orcid.org/0000-0003-1292-1352)
Institutions
- University of Freiburg (DE)
- German Cancer Research Center (DE)
- University Medical Center Freiburg (DE)
- Helmholtz Zentrum München (DE)
- Essen University Hospital (DE)
- Centre de Coopération Universitaire Franco-Bavarois (DE)
- German Centre for Cardiovascular Research (DE)
- German Center for Diabetes Research (DE)
- University of Duisburg-Essen (DE)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-25
- DOI
- https://doi.org/10.3389/fonc.2025.1613884
- Primary Topic
- Oral health in cancer treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Bundesministerium für Bildung und Forschung
- Universität Duisburg-Essen