Altered white matter connection from the locus coeruleus to the thalamus in Parkinson's disease
This study shows the feasibility to visualize the LC-thalamic tract with the use of 7T DWI data. The results provide evidence of the association between the integrity of the white matter tracts and early PD development, highlighting its potential as a target for therapeutic interventions. Further research is needed to elucidate the role of the LC and its white matter connections in the progression of PD and neuropsychiatric and other symptoms.
Authors
- Jacobus F.A. Jansen (ORCID: https://orcid.org/0000-0002-5271-8060)
- Monique Heijmans (ORCID: https://orcid.org/0000-0003-2266-3596)
- Mark L. Kuijf (ORCID: https://orcid.org/0000-0002-7284-5833)
- Meriek Wanders
- Yasin Temel (ORCID: https://orcid.org/0000-0002-3589-5604)
- Stijn Michielse (ORCID: https://orcid.org/0000-0003-3930-8646)
- A. J. P. Wolters
Institutions
- Radboud University Nijmegen (NL)
- Catharina Ziekenhuis (NL)
- Maastricht University (NL)
- Eindhoven University of Technology (NL)
Publication Details
- Journal
- Neuroimage Reports
- Published
- 2025-09-27
- DOI
- https://doi.org/10.1016/j.ynirp.2025.100292
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Stichting De Weijerhorst