131I therapy for benign thyroid disease: flexible single-time-point dosimetry using population-based model selection with non-linear mixed-effects modelling
While s1TIA typically produced better <sup>131</sup>I TIA estimates for benign thyroid disease than the hTIA recommended in the EANM SOP, the STP calculation from NLMEM using SOEF EANM SOP s2TIAs was inferior to hTIA. With the best SOEF model, NLMEM provides satisfactory and reasonable STP estimates.
Authors
- Ade Riana
- Ambros J. Beer (ORCID: https://orcid.org/0000-0001-9042-7806)
- Gerhard Glatting (ORCID: https://orcid.org/0000-0001-7916-1576)
- Deni Hardiansyah (ORCID: https://orcid.org/0000-0003-0984-8967)
- Michael Laßmann (ORCID: https://orcid.org/0000-0002-2556-1977)
- Heribert Hänscheid (ORCID: https://orcid.org/0000-0003-1366-911X)
- Jaja Muhamad Jabar
Institutions
- Bandung Institute of Technology (ID)
- Universität Ulm (DE)
- University of Indonesia (ID)
- Nuclear and Radiation Safety Center (CN)
- Universitätsklinikum Würzburg (DE)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1186/s40658-025-00806-8
- Citations
- 1
- Primary Topic
- Statistical Methods in Clinical Trials
- Type
- article
- Field-Weighted Citation Impact
- 2.63
Funders
- Deutscher Akademischer Austauschdienst
- Universitas Indonesia
- Bundesministerium für Wirtschaftliche Zusammenarbeit und Entwicklung
- Ipsen
- Lembaga Pengelola Dana Pendidikan