A Short Route to Midazolam via Michael Addition to a Nitroolefin
A new approach to midazolam through Michael addition of 2-aminobenzophenone with a nitroolefin as a key step is reported. We devised a telescoped four-step synthesis using only one single protecting group, resulting in an excellent atom economy.
Authors
- B. Frank Gupton (ORCID: https://orcid.org/0000-0002-8165-1088)
- Kai Donsbach (ORCID: https://orcid.org/0000-0001-5942-1553)
- Till Opatz (ORCID: https://orcid.org/0000-0002-3266-4050)
- Lara Brunotte
Institutions
- Virginia Commonwealth University (US)
- Johannes Gutenberg University Mainz (DE)
- Life University (US)
Publication Details
- Journal
- Organic Process Research & Development
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1021/acs.oprd.5c00320
- Primary Topic
- Asymmetric Synthesis and Catalysis
- Type
- article
- Field-Weighted Citation Impact
- 0.00