The Emerging Role of Magnesium in Preventing Acute Kidney Disease During Concurrent Chemoradiotherapy in Head and Neck Cancer
In a real-world cohort receiving high-dose cisplatin with structured nephroprotection including IV magnesium, AKD developed in approximately 10% of patients. Lower baseline eGFR, elevated BMI, and RAAS inhibitor use emerged as potential risk factors. These findings reinforce the importance of proactive renal monitoring and suggest a role for magnesium supplementation as an accessible strategy to enhance renal safety in curative-intent CRT.
Authors
- Aurora Mirabile (ORCID: https://orcid.org/0000-0002-1475-0940)
- Francesco Trevisani (ORCID: https://orcid.org/0000-0003-4205-8959)
- Matteo Floris (ORCID: https://orcid.org/0000-0003-4385-9336)
- Leone Giordano (ORCID: https://orcid.org/0000-0001-9094-4205)
- M. Agnese (ORCID: https://orcid.org/0000-0001-5829-5954)
- Andrea Angioi (ORCID: https://orcid.org/0000-0001-8311-5409)
- Cardellini Sara (ORCID: https://orcid.org/0000-0001-8006-6197)
- Culiersi Alberta
Institutions
- Vita-Salute San Raffaele University (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Azienda Ospedaliera G. Brotzu (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3390/cancers17203310
- Primary Topic
- Esophageal and GI Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00