Exploring the Causal Relationships and Mediating Factors Between Mental Disorders and Hypertension: A Multivariable Mendelian Randomization Study
This study provided compelling evidence supporting a bidirectional phenotypic association between depression and hypertension, while highlighting diabetes and smoking as significant mediators in the association's pathway to hypertension development.
Authors
- Jun Jin (ORCID: https://orcid.org/0000-0003-1306-150X)
- Dong Wang (ORCID: https://orcid.org/0000-0001-9040-1657)
- Z T Gao (ORCID: https://orcid.org/0000-0002-0200-0173)
- Chun Yin (ORCID: https://orcid.org/0000-0001-8462-4096)
- Kunyan Li (ORCID: https://orcid.org/0000-0002-5901-9780)
- Hong Mian Yang (ORCID: https://orcid.org/0000-0002-1437-9539)
Institutions
- Army Medical University (CN)
- People's Liberation Army 401 Hospital (CN)
- Xinqiao Hospital (CN)
Publication Details
- Journal
- Global Heart
- Published
- 2025-10-14
- DOI
- https://doi.org/10.5334/gh.1483
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00