Lysosomal Ca <sup>2+</sup> Release Through TRPML1 Governs Ventricular Arrhythmia After Myocardial Infarction
Lysosomes contribute to arrhythmic risk after MI because of increased number, proximity to the SR, and induction of diastolic SR Ca<sup>2+</sup> release mediated by TRPML1-dependent lysosomal Ca<sup>2+</sup> release.
Authors
- Samuel C. Dudley (ORCID: https://orcid.org/0000-0001-5843-5961)
- Hong Liu (ORCID: https://orcid.org/0000-0002-4079-6985)
- Dobromir Dobrev (ORCID: https://orcid.org/0000-0002-4612-117X)
- Gyeoung-Jin Kang (ORCID: https://orcid.org/0000-0003-0646-9187)
- Feng Feng (ORCID: https://orcid.org/0000-0001-9912-4318)
- An Xie
- Eun Ji Kim (ORCID: https://orcid.org/0000-0002-3271-1419)
Institutions
- Baylor College of Medicine (US)
- Montreal Heart Institute (CA)
- Minneapolis Heart Institute Foundation (US)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Circulation Arrhythmia and Electrophysiology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1161/circep.125.013964
- Primary Topic
- Calcium signaling and nucleotide metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00