Genetic variation in the glucagon-like peptide-1 receptor protein encoding region is associated with higher heart rate variability, but not with neurodegeneration of the brain, retina, and peripheral nerves: The Maastricht study
Higher putative GLP1R protein expression, assessed from genetic variation in the GLP1R protein encoding region, was significantly associated with lower levels of neurodegeneration in the heart, but not in the brain, retina, and peripheral nerves. Future clinical trials should test whether use of GLP1R agonists can contribute to prevention of cardiac autonomic nerve degeneration and associated clinical disease.
Authors
- Anke Wesselius (ORCID: https://orcid.org/0000-0003-4474-9665)
- Coen D.A. Stehouwer (ORCID: https://orcid.org/0000-0001-8752-3223)
- Tos T. J. M. Berendschot (ORCID: https://orcid.org/0000-0002-8101-939X)
- Jacobus F.A. Jansen (ORCID: https://orcid.org/0000-0002-5271-8060)
- Marleen M. J. van Greevenbroek (ORCID: https://orcid.org/0000-0002-2989-1631)
- Ilja C.W. Arts (ORCID: https://orcid.org/0000-0001-6462-6692)
- Miranda T. Schram (ORCID: https://orcid.org/0000-0001-8113-7604)
- Walter H. Backes (ORCID: https://orcid.org/0000-0001-7905-0681)
- Indra L. M. Steens (ORCID: https://orcid.org/0000-0002-9025-2011)
- Archana Singh‐Manoux (ORCID: https://orcid.org/0000-0002-1244-5037)
- Tan Lai Zhou (ORCID: https://orcid.org/0000-0003-3464-7374)
- Carroll A.B. Webers (ORCID: https://orcid.org/0000-0001-5605-740X)
- Carla Kallen (ORCID: https://orcid.org/0000-0003-1468-8793)
- Sèverine Sabia (ORCID: https://orcid.org/0000-0003-3109-9720)
- Gabriëlla A.M. Blokland (ORCID: https://orcid.org/0000-0003-0566-444X)
- Thomas T. van Sloten (ORCID: https://orcid.org/0000-0003-2870-482X)
- Frank C. T. van der Heide (ORCID: https://orcid.org/0000-0003-1131-2184)
- Sebastian Köhler (ORCID: https://orcid.org/0000-0002-2398-0609)
Institutions
- Inserm (FR)
- Utrecht University (NL)
- Université Paris Cité (FR)
- Maastricht University Medical Centre (NL)
- Erasmus MC (NL)
- University Medical Center Utrecht (NL)
- Maastricht University (NL)
- Sorbonne Paris Cité (FR)
- Fondation de Rothschild (FR)
- Center for Translational Molecular Medicine (NL)
- Eindhoven University of Technology (NL)
- Erasmus University Rotterdam (NL)
- KU Leuven (BE)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s12933-025-02888-1
- Citations
- 1
- Primary Topic
- Heart Rate Variability and Autonomic Control
- Type
- article
- Field-Weighted Citation Impact
- 1.39