TCN1 Drives Malignant Progression of Pancreatic Cancer Through STAT4-Mediated Transcriptional Activation of the DUOX2/ROS Signaling Axis
Collectively, our findings reveal a novel TCN1/STAT4/DUOX2 regulatory axis that exacerbates PDAC progression by remodeling redox homeostasis. This signaling cascade may serve as a prognostic biomarker and a potential therapeutic target for ROS-directed precision therapy in PDAC.
Authors
- Dongbo Xue (ORCID: https://orcid.org/0000-0001-9012-4805)
- Zonglin Liu
- Ze Yu
- Dongsheng Ju
- Yongwei Wang (ORCID: https://orcid.org/0000-0001-9712-8964)
- B. Zhang
Institutions
- Ministry of Education of the People's Republic of China (CN)
- Harbin Medical University (CN)
- First Affiliated Hospital of Harbin Medical University (CN)
Publication Details
- Journal
- Cancers
- Published
- 2025-10-12
- DOI
- https://doi.org/10.3390/cancers17203300
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Harbin Medical University