Hypokalemic Periodic Paralysis: A Case Report

Hypokalaemic periodic paralysis (HPP) is a rare neuromuscular disorder characterized by recurrent episodes of transient muscle weakness associated with hypokalaemia. The condition typically presents in childhood or adolescence. In this case, a 17-year-old male presented with acute-onset limb weakness upon waking. Examination revealed marked truncal and proximal muscle weakness with preserved distal strength. Serum potassium was 2.7 mmol/L. His symptoms fully resolved following intravenous potassium replacement. HPP is often underdiagnosed, and diagnostic delays can leave patients vulnerable to avoidable complications, including recurrent episodes and potentially life-threatening arrhythmias. This case highlights the importance of considering HPP in young patients presenting with acute muscle weakness and hypokalaemia.

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Journal
Cureus
Published
2025-10-14
DOI
https://doi.org/10.7759/cureus.94524
Primary Topic
Ion Transport and Channel Regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

Hypokalemic Periodic Paralysis: A Case Report

Zara Marchant, Mohsin Wani, Umed Nadir
Cureus
Ion Transport and Channel Regulation
article

Hypokalemic Periodic Paralysis: A Case Report

Zara Marchant, Mohsin Wani, Umed Nadir
article en

Abstract

Hypokalaemic periodic paralysis (HPP) is a rare neuromuscular disorder characterized by recurrent episodes of transient muscle weakness associated with hypokalaemia. The condition typically presents in childhood or adolescence. In this case, a 17-year-old male presented with acute-onset limb weakness upon waking. Examination revealed marked truncal and proximal muscle weakness with preserved distal strength. Serum potassium was 2.7 mmol/L. His symptoms fully resolved following intravenous potassium replacement. HPP is often underdiagnosed, and diagnostic delays can leave patients vulnerable to avoidable complications, including recurrent episodes and potentially life-threatening arrhythmias. This case highlights the importance of considering HPP in young patients presenting with acute muscle weakness and hypokalaemia.

CureusVol. 17(10)
Royal Hampshire County Hospital (GB), Hampshire Hospitals NHS Foundation Trust (GB)
Openalex Percentile: Top 74%
Ion Transport and Channel Regulation
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