A comparative study on the efficacy of different combinational anti-seizure medication therapies following valproate monotherapy failure
In this real-world study, we assessed the effectiveness of five anti-seizure medications as add-on therapy for PWE who failed sodium valproate monotherapy. Our findings suggest that combining LTG may be more effective for subjects with generalized epilepsy, while combining OXC may be more effective for subjects with focal epilepsy.
Authors
- Nanya Hao (ORCID: https://orcid.org/0000-0003-4639-0721)
- Enhui Zhang (ORCID: https://orcid.org/0000-0003-3345-8934)
- Xintong Wu (ORCID: https://orcid.org/0000-0002-7676-3288)
- Dong Chi Zhou (ORCID: https://orcid.org/0000-0001-7101-4125)
- Yujie Chen (ORCID: https://orcid.org/0000-0002-1056-0840)
- Jia He (ORCID: https://orcid.org/0000-0002-7261-9852)
- Rui Yan (ORCID: https://orcid.org/0000-0002-8925-3148)
- Hesheng Zhang (ORCID: https://orcid.org/0000-0003-4489-2103)
- Zhujing Ou
- Wenyu Liu (ORCID: https://orcid.org/0000-0002-0455-3847)
Institutions
- Sichuan University (CN)
- West China Hospital of Sichuan University (CN)
Publication Details
- Journal
- Acta Epileptologica
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1186/s42494-025-00233-3
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sichuan University
- Natural Science Foundation of Sichuan Province
- Health Commission of Sichuan Province
- West China Hospital, Sichuan University