Allopurinol Attenuates Senescence and Oxidative Stress in Endothelial Cells Exposed to Serum from Hypertensive Patients with Hyperuricemia - a Pilot Study
Allopurinol partially reverses uric acid- and hypertension-related endothelial senescence and oxidative damage, but incomplete normalisation suggests multiple overlapping pathways contribute to vascular cell senescence in this context.
Authors
- Andrzej Tykarski (ORCID: https://orcid.org/0000-0001-9786-6334)
- Justyna Mikuła‐Pietrasik (ORCID: https://orcid.org/0000-0002-8267-5428)
- Paweł Uruski (ORCID: https://orcid.org/0000-0002-6798-3043)
- Krzysztof Książek (ORCID: https://orcid.org/0000-0002-6066-5747)
- Katarzyna Lewandowska (ORCID: https://orcid.org/0000-0002-6385-886X)
Institutions
- Poznan University of Medical Sciences (PL)
- Heliodor Swiecicki Clinical Hospital (PL)
Publication Details
- Journal
- Cellular Physiology and Biochemistry
- Published
- 2025-10-14
- DOI
- https://doi.org/10.33594/000000819
- Primary Topic
- Gout, Hyperuricemia, Uric Acid
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu