Epigenetic alterations of serotonergic but not dopaminergic signalling in compulsive sexual behaviour disorder
Overall, these findings suggest that dysregulation of serotonergic signalling might contribute to the CSBD etiology and further exploration of this avenue with larger sample sizes might be beneficial to our understanding of compulsive sexuality. We found no evidence of epigenetic dysregulation in dopaminergic target genes. The lack of association of methylation rates and sexual outlet in CSBD individuals is indicative of the lack of epigenetic regulatory feedback, hence of potentially abnormal signalling of sexual drive and satiety.
Authors
- Christopher Sinke (ORCID: https://orcid.org/0000-0003-1716-6229)
- Jonas Kneer (ORCID: https://orcid.org/0000-0002-8980-4595)
- Helge Frieling (ORCID: https://orcid.org/0000-0001-5146-9720)
- Maria Veit (ORCID: https://orcid.org/0000-0003-1154-2705)
- Renáta Androvičová (ORCID: https://orcid.org/0000-0002-1099-0891)
- Jannis Engel (ORCID: https://orcid.org/0000-0002-9334-3891)
- Michał Lew‐Starowicz (ORCID: https://orcid.org/0000-0002-0283-0839)
- Kirsten Jahn (ORCID: https://orcid.org/0000-0002-2760-1602)
- Tillmann H. C. Krüger (ORCID: https://orcid.org/0000-0002-6583-1433)
- Sunyu Sun
Institutions
- Medizinische Hochschule Hannover (DE)
- Postgraduate School of Molecular Medicine (PL)
- National Institute of Mental Health (CZ)
Publication Details
- Journal
- Behavioural Brain Research
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1016/j.bbr.2025.115872
- Citations
- 1
- Primary Topic
- Sexuality, Behavior, and Technology
- Type
- article
- Field-Weighted Citation Impact
- 2.31