Circulating plasma exosomal miR-146b-5p regulates microglial-mediated neuroinflammation through the TRAF6/NF-κB signaling axis after intracerebral hemorrhage
Circulating plasma exosomal miR-146b-5p modulates microglial polarization and neuroinflammation via the TRAF6/NF-κB signaling pathway following ICH, providing neuroprotective benefits. These findings may contribute to the development of innovative therapeutic approaches.
Authors
- Lanying Zhang (ORCID: https://orcid.org/0000-0003-1994-8531)
- Rong Hu (ORCID: https://orcid.org/0000-0001-8597-1567)
- Ning Ding (ORCID: https://orcid.org/0000-0002-8701-7635)
- Peirui Wang (ORCID: https://orcid.org/0009-0008-6293-8957)
- Fuan Zhang
- Ziqiang Chen (ORCID: https://orcid.org/0000-0002-7490-6273)
- Jiao Chen (ORCID: https://orcid.org/0000-0003-0830-6242)
- Xuyang Zhang (ORCID: https://orcid.org/0000-0002-4665-3934)
- Fang Cao (ORCID: https://orcid.org/0000-0001-5684-8121)
- Fengchun Zhao
- Chong Han (ORCID: https://orcid.org/0000-0002-8520-6029)
- Shengtao Yao (ORCID: https://orcid.org/0000-0002-8354-4198)
Institutions
- Army Medical University (CN)
- Zunyi Medical University (CN)
- Southwest Hospital (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1016/j.lfs.2025.124023
- Citations
- 2
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78