Orodispersible Liquisolid Dosage Form: A Recent Pharmaceutical Era of Drug Delivery System

The orodispersible liquisolid system represents an innovative breakthrough in the pharmaceutical field. It combines liquisolid technology with the orodispersible system. In recent years, many drug candidates have been formulated, most of which are lipophilic with poor water solubility. The liquisolid system is ideal for such drugs that exhibit low or no water solubility, possess high permeability (BCS Class II), and necessitate either sustained or immediate release. Powder solution technology, also known as liquisolid formulation, is the process of transforming liquid pharmaceuticals (drugs in solution or suspension) in non-volatile solvents by mixing the solution with suitable carriers and coating agents to create cohesive-free, readily flowable, and compressible powder blends. Orodispersible tablets are becoming more popular as innovative oral drug delivery systems because they can break down into smaller granules or a gel-like form in less than three minutes, making it easier for patients to swallow. Orodispersible tablets provide a fast onset of action due to the inclusion of super disintegrants, which allows for quick absorption through the medication's pre-gastric uptake from the palate, throat, and oesophagus during the swallowing of saliva. This aids in dose reduction. Furthermore, they promote patient compliance and enable proper oral administration for children and elderly individuals who find it challenging to swallow. By using both liquisolid and orodispersible systems, one may improve the dissolution speed, solubility, and bioavailability of medications while achieving a rapid onset of accompanying pharmacodynamic effects. This review study significantly helps readers and researchers understand this novel pharmaceutical dosage form. This article explores the concept and practical use of the orodispersible liquisolid compact method to enhance bioavailability and solubility.