Magnetic Liposomes for Remote Controlled High-Molecular Drugs Release under a Low-Frequency Non-Heating Magnetic Field
Magnetic anionic liposomes (MALip) conjugated with magnetite magnetic nanoparticles (MNPs) are developed for the controlled release of a protease inhibitor (BBI) under exposure to a low-frequency nonheating magnetic field (LF AMF). It is shown that an increase of up to 35% of the protein release rate occurred when the MALip are exposed to the LF AMF (frequency 110 Hz, intensity 75–150 kA/m) for 5–15 min. The research provides prospects for the development of remotely controlled protein release from liposomes.
Authors
- A. V. Petrunin
- Yu. I. Golovin
- S. Ch. Vanzarakshaeva
- Irina M. Le‐Deygen (ORCID: https://orcid.org/0000-0002-6366-4491)
- Natalia L. Klyachko (ORCID: https://orcid.org/0000-0002-9357-8236)
- Maxim M. Veselov (ORCID: https://orcid.org/0000-0002-8983-2772)
- Alexander V. Kabanov (ORCID: https://orcid.org/0000-0002-3665-946X)
- А. Н. Прусов (ORCID: https://orcid.org/0000-0001-6731-2031)
- A. B. Shuklinov
- Kseniya Yu. Vlasova (ORCID: https://orcid.org/0000-0003-3774-1323)
Institutions
- University of North Carolina at Chapel Hill (US)
Publication Details
- Journal
- UNC Libraries
- Published
- 2025-10-14
- DOI
- https://doi.org/10.17615/9gkq-2n13
- Primary Topic
- Nanoparticle-Based Drug Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00