Synthesis of Indeno-Quinolones and Their Functionalization toward 5-HT <sub>3</sub> Receptor
A practical and sustainable approach for the synthesis of bioactive indeno-quinolinones has been developed via <i>tert</i>-butyl hydroperoxide-mediated cross-dehydrogenative coupling. This metal and photocatalyst-free protocol proceeds under mild conditions and demonstrates broad substrate scope and operational simplicity. The potential for late-stage functionalization underscores the utility of this method in the efficient synthesis of bioactive compounds such as 5-HT<sub>3</sub> receptor and TAS-103 analogues.
Authors
- K. Rajender Reddy (ORCID: https://orcid.org/0000-0002-6885-2387)
- Kirti Vashishtha
- Kapil Chahal (ORCID: https://orcid.org/0000-0002-5825-5810)
- Vijaya Rani Potluri
- Donamol Tomy
Institutions
- Indian Institute of Chemical Technology (IN)
- Academy of Scientific and Innovative Research (IN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1021/acs.joc.5c01433
- Primary Topic
- Synthesis and Biological Evaluation
- Type
- article
- Field-Weighted Citation Impact
- 0.00