Elevated Th1 and terminally differentiated cytotoxic T cells with suppressed Tc17 lymphocytes in lung tissue of advanced COPD and IPF patients undergoing lung transplantation
Our findings identify disease-specific immune signatures in end-stage COPD and IPF. Th1 cell expansion together with a reduction in Tc17 and DN TRM subsets represented shared features of COPD and IPF, whereas accumulation of terminally differentiated cytotoxic CD8<sup>+</sup> T cells and CD25<sup>+</sup> DN T cells was specific to COPD. These findings enhance our understanding of adaptive immune dysregulation in COPD and IPF and may support the development of immunomodulatory strategies.
Authors
- Luka Dejanović (ORCID: https://orcid.org/0009-0002-1973-1869)
- Matthias Zimmermann (ORCID: https://orcid.org/0000-0002-4610-7853)
- Ana Koren (ORCID: https://orcid.org/0000-0002-9671-1645)
- Matija Rijavec (ORCID: https://orcid.org/0000-0002-2596-4952)
- Peter Korošec (ORCID: https://orcid.org/0000-0002-0835-1599)
- Hendrik Jan Ankersmit (ORCID: https://orcid.org/0000-0002-8761-3517)
- Irena Šarc (ORCID: https://orcid.org/0000-0001-6053-7406)
Institutions
- University of Ljubljana (SI)
- Ljubljana University Medical Centre (SI)
- Biotechnical Educational Centre Ljubljana (SI)
- Christian Doppler Laboratory for Thermoelectricity (AT)
- University Clinic of Pulmonary and Allergic Diseases Golnik (SI)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1646711
- Citations
- 1
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- Universität Wien
- Javna Agencija za Raziskovalno Dejavnost RS
- Medizinische Universität Wien