Neuroprotective synergy of curcumin and Glycyrrhiza glabra in an alzheimer’s model: implications for inflammation and redox pathways
Co-administration of curcumin and <i>Glycyrrhiza glabra</i> exerts synergistic neuroprotective effects by attenuating neuroinflammation, oxidative stress, and AD-related protein expression, surpassing monotherapy outcomes. These findings suggest a synergistic neuroprotective mechanism via modulation of TLR4/MyD88/NF-κB and redox pathways. This study provides preclinical evidence supporting the development of TCM-based combination strategies for AD intervention.
Authors
- Jianwei Dong (ORCID: https://orcid.org/0000-0002-0547-2870)
- Shanshan Liu (ORCID: https://orcid.org/0000-0003-0533-933X)
- Jing Yan (ORCID: https://orcid.org/0000-0002-5264-8197)
Institutions
- Union Hospital (HK)
- Wuhan Union Hospital (CN)
- Huazhong University of Science and Technology Hospital (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fphar.2025.1661706
- Citations
- 1
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.56