Neuroprotective synergy of curcumin and Glycyrrhiza glabra in an alzheimer’s model: implications for inflammation and redox pathways

Co-administration of curcumin and <i>Glycyrrhiza glabra</i> exerts synergistic neuroprotective effects by attenuating neuroinflammation, oxidative stress, and AD-related protein expression, surpassing monotherapy outcomes. These findings suggest a synergistic neuroprotective mechanism via modulation of TLR4/MyD88/NF-κB and redox pathways. This study provides preclinical evidence supporting the development of TCM-based combination strategies for AD intervention.

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Publication Details

Journal
Frontiers in Pharmacology
Published
2025-10-14
DOI
https://doi.org/10.3389/fphar.2025.1661706
Citations
1
Primary Topic
Pharmacological Effects of Natural Compounds
Type
article
Field-Weighted Citation Impact
1.56
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article

Neuroprotective synergy of curcumin and Glycyrrhiza glabra in an alzheimer’s model: implications for inflammation and redox pathways

Jianwei Dong, Shanshan Liu, Jing Yan
1 citations
Frontiers in Pharmacology
Pharmacological Effects of Natural Compounds
1.56
article

Neuroprotective synergy of curcumin and Glycyrrhiza glabra in an alzheimer’s model: implications for inflammation and redox pathways

Jianwei Dong, Shanshan Liu, Jing Yan
article en
1 citations

Abstract

Co-administration of curcumin and <i>Glycyrrhiza glabra</i> exerts synergistic neuroprotective effects by attenuating neuroinflammation, oxidative stress, and AD-related protein expression, surpassing monotherapy outcomes. These findings suggest a synergistic neuroprotective mechanism via modulation of TLR4/MyD88/NF-κB and redox pathways. This study provides preclinical evidence supporting the development of TCM-based combination strategies for AD intervention.

Frontiers in PharmacologyVol. 16
Union Hospital (HK), Wuhan Union Hospital (CN), Huazhong University of Science and Technology Hospital (CN), Union Hospital (CN)
Openalex Percentile: Top 14%
Pharmacological Effects of Natural Compounds
1.56
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