Interplay between host genetics and gut microbiome composition in the Japanese population
Our findings enhance the understanding of how host genetics shape the gut microbiota in the Japanese population and underscore the importance of methodological standardization in microbiome research. The identified associations between host genetic variants and specific microbial taxa provide insights into the complex interplay between genetics and the gut microbiome. Addressing methodological discrepancies is crucial for improving reproducibility and advancing knowledge of host-microbiome interactions.
Authors
- Momoko Horikoshi (ORCID: https://orcid.org/0000-0002-7103-2267)
- Tetsuya Kubota (ORCID: https://orcid.org/0000-0003-0341-3137)
- Chikashi C. Terao (ORCID: https://orcid.org/0000-0002-6452-4095)
- Kohei Tomizuka (ORCID: https://orcid.org/0000-0003-0165-8763)
- Takashi Kadowaki (ORCID: https://orcid.org/0000-0002-5428-3582)
- Wataru Suda (ORCID: https://orcid.org/0000-0002-2861-9724)
- Takuro Iwami (ORCID: https://orcid.org/0000-0001-9190-6526)
- Hiroshi Ohno (ORCID: https://orcid.org/0000-0001-8776-9661)
- Yusuke Ogata (ORCID: https://orcid.org/0000-0002-5993-4356)
- David Ortega-Reyes
- Naoto Kubota (ORCID: https://orcid.org/0000-0002-3336-2767)
- Tadashi Takeuchi
Institutions
- National Institute of Genetics (JP)
- University of Shizuoka (JP)
- Chiba University (JP)
- The Graduate University for Advanced Studies, SOKENDAI (JP)
- Keio University (JP)
- National Institute of Biomedical Innovation, Health and Nutrition (JP)
- The Institute of Medical Science, Asahi Life Foundation (JP)
- Shizuoka General Hospital (JP)
- RIKEN Center for Integrative Medical Sciences (JP)
- Toranomon Hospital (JP)
- The University of Tokyo (JP)
- Yokohama City University (JP)
- Kumamoto University (JP)
Publication Details
- Journal
- Frontiers in Microbiomes
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/frmbi.2025.1635907
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Agency for Medical Research and Development
- Japan Society for the Promotion of Science