Sputum host cytokine signatures for diagnosis of TB in children and adults
This study describes the use of host markers in sputum for development of a rapid triage test for pulmonary TB in adults and children. Whilst the results are promising for regional-specific and treatment response signatures, our pilot data do not support development of a global test for TB triage based on sputum host signatures.
Authors
- Joseph Mendy
- Edward Coker
- Novel N. Chegou (ORCID: https://orcid.org/0000-0002-8690-1699)
- January Weiner (ORCID: https://orcid.org/0000-0003-1438-7819)
- Jayne S. Sutherland (ORCID: https://orcid.org/0000-0002-7083-4997)
- Gian van der Spuy (ORCID: https://orcid.org/0000-0002-9067-5903)
Institutions
- South African Medical Research Council (ZA)
- MRC Unit the Gambia (GM)
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fimmu.2025.1652719
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Charities Group
- UK Research and Innovation
- Medical Research Council