Imidazole-2-thione and Acylhydrazone Derivatives Targeting Carbonic Anhydrase-II: Synthesis, In Vitro Evaluations, and MM-GBSA Calculation
These findings suggest that the synthesized 5NBIT and acylhydrazone derivatives exhibited potent CA-II inhibition, with several compounds outperforming the standard drug acetazolamide. These results provide valuable insights for the development of novel CA-II inhibitors with potential therapeutic applications in glaucoma and other related conditions.
Authors
- Manzoor Ahmad (ORCID: https://orcid.org/0000-0002-4878-0996)
- Sobia Ahsan Halim (ORCID: https://orcid.org/0000-0001-8526-7799)
- Muhammad Ibrahim (ORCID: https://orcid.org/0000-0003-1672-8955)
- Abdul Latif (ORCID: https://orcid.org/0000-0002-9047-7747)
- M. A. Khan
- Ahmed Al‐Harrasi (ORCID: https://orcid.org/0000-0002-0815-5942)
- Jalal Uddin (ORCID: https://orcid.org/0000-0002-8613-4493)
- Muhammad Waqas (ORCID: https://orcid.org/0000-0001-6115-9689)
- Nazia Akbar (ORCID: https://orcid.org/0000-0003-2203-4933)
- Samee Ullah
- Majid Khan (ORCID: https://orcid.org/0000-0001-5233-2187)
- Mumtaz Ali
- Sajid Ali
Institutions
- University of Nizwa (OM)
- Hazara University (PK)
- University of Malakand (PK)
- King Khalid University (SA)
Publication Details
- Journal
- Current Medicinal Chemistry
- Published
- 2025-10-14
- DOI
- https://doi.org/10.2174/0109298673365555250617114928
- Primary Topic
- Enzyme function and inhibition
- Type
- article
- Field-Weighted Citation Impact
- 0.00