Complement C4 gene copy numbers modulate serum immune protein profiles in patients with first-episode psychosis and healthy controls in a sex-specific manner
C4A and C4B gene copy variations influence immunoinflammatory responses and serum levels of many immune proteins. This phenomenon was pronounced in male FEP patients, suggesting that they may be more vulnerable to tissue injury or infections. The results underscore the importance of investigating sex-specific effects of C4 gene variations in psychotic disorders.
Authors
- Jarno Honkanen (ORCID: https://orcid.org/0000-0001-8854-3744)
- Seppo Meri (ORCID: https://orcid.org/0000-0001-9142-501X)
- Vesa Vahermaa (ORCID: https://orcid.org/0000-0001-7222-6779)
- Uni Rankka (ORCID: https://orcid.org/0009-0006-0061-627X)
- Heikki Laurikainen (ORCID: https://orcid.org/0000-0002-6323-4475)
- Jarmo Hietala (ORCID: https://orcid.org/0000-0002-3179-6780)
- Jaana Suvisaari (ORCID: https://orcid.org/0000-0001-7167-0990)
- Marja‐Liisa Lokki
Institutions
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- Turku University Hospital (FI)
- Finnish Institute for Health and Welfare (FI)
- Hospital District of Helsinki and Uusimaa (FI)
- Aalto University (FI)
Publication Details
- Journal
- Schizophrenia Research
- Published
- 2025-10-14
- DOI
- https://doi.org/10.1016/j.schres.2025.10.001
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00