<i>Syringa pinnatifolia</i> Lignans Contribute to the Cardioprotective Effect Against Ischemic Injury through the Nrf2/HO‐1 Signaling Pathway in Vitro and in Vivo
As part of a systematic study, this research aims to investigate the protective effects of subfraction I<sub>3</sub> from Syringa pinnatifolia against oxidative damage following acute myocardial infarction (AMI) in mice and its underlying mechanisms. The I<sub>3</sub> was chemically characterized by using IT-TOF-ESI-MS. The anti-AMI effects of fraction C and subfractions I<sub>2</sub> and I<sub>3</sub> were evaluated by using H&E staining, immunofluorescence, and Western blotting. The results showed that I<sub>3</sub> improves the impaired cardiac function, bringing it to a level comparable to that of C in vivo and/or in vitro, whereas I<sub>2</sub> did not exhibit this effect, suggesting the lignan rather than terpenoid fraction contributes the anti-AMI effect of S. pinnatifolia, and the mechanism of action may be related to the promotion of the Nrf2/HO-1 signaling pathway activation.
Authors
- Kelsang Norbu
- Guodong Yang (ORCID: https://orcid.org/0000-0002-6307-2963)
- Xingyun Chai (ORCID: https://orcid.org/0000-0003-1321-7543)
- Jessore Jurat
- Changxin Liu (ORCID: https://orcid.org/0000-0001-7353-9830)
- Feng Zhou (ORCID: https://orcid.org/0000-0001-6122-0611)
- Wenfu Ma (ORCID: https://orcid.org/0000-0002-1763-8719)
- Xiaojuan Li (ORCID: https://orcid.org/0009-0009-8408-4590)
- Xiaoli Gao (ORCID: https://orcid.org/0000-0002-6974-832X)
- Xiaojing Ma (ORCID: https://orcid.org/0000-0002-3584-0769)
- Qiuyuan Ding
Institutions
- Beijing University of Chinese Medicine (CN)
- Tibetan Traditional Medical College (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1002/cbdv.202502483
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00