Salt taste perception, dietary salt intake, cardiovascular health and genetic variation in Zambian adults with HIV
PLWH consumed more salt than HC, which may be driven by a reduced salt perception. Additionally, differences were found in the association between the TRPV1 rs4790522 SNP, salt intake and BMI profiles, between PLWH and HC, suggesting a gene-environment-disease interaction. Future research should validate these associations in larger cohorts and explore interventions addressing genetic and sensory contributors to hypertension in high-risk SSA populations.
Authors
- Sepiso K. Masenga (ORCID: https://orcid.org/0000-0003-4376-5831)
- J.D. Nixon (ORCID: https://orcid.org/0000-0002-4584-5491)
- Joreen P. Povia (ORCID: https://orcid.org/0009-0006-7438-1549)
- Leta Pilić (ORCID: https://orcid.org/0000-0001-8046-1269)
- Annet Kirabo (ORCID: https://orcid.org/0000-0001-8580-9359)
- Catherine Graham (ORCID: https://orcid.org/0000-0002-9129-1151)
Institutions
- University of Lucerne (CH)
- Vanderbilt University (US)
- St Mary's University Twickenham London (GB)
- Mulungushi University (ZM)
- Optimat (United Kingdom) (GB)
- Vanderbilt Health (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fphys.2025.1616785
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00