Pulmonary function impairment and its relationship with target therapy response in patients with pulmonary arterial hypertension
PAH patients exhibited impairment in both ventilation and diffusion capacity, while patients with diverse etiologies demonstrated distinct characteristics. FVC and FEV<sub>1</sub> were positively correlated with 6MWD, respectively. PAH patients with FVC% pred values below 82% demonstrated a diminished response to PAH-targeted therapy.
Authors
- Mengshuang Xie (ORCID: https://orcid.org/0000-0002-3132-5890)
- Xiaopei Cui (ORCID: https://orcid.org/0000-0002-9724-6175)
- Weida Lu (ORCID: https://orcid.org/0000-0001-7547-1833)
- Haijun Li (ORCID: https://orcid.org/0000-0002-9240-1930)
- Junjun Liu (ORCID: https://orcid.org/0000-0001-9953-8633)
- Qiushang Ji (ORCID: https://orcid.org/0000-0002-4532-7096)
- Zhao Yang (ORCID: https://orcid.org/0000-0003-4668-6127)
- Xia Xu (ORCID: https://orcid.org/0009-0006-9104-8123)
Institutions
- Community Health Center (US)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-10-14
- DOI
- https://doi.org/10.3389/fmed.2025.1616252
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province