Combined MYC Activation and PTEN Loss Drives Molecular Features of Aggressive Preinvasive Lesions in Mouse Prostate
Increased cell cycle and translational machinery gene induction may explain the synergy between MYC and PTEN loss for increasing prostate cancer cell proliferation and disease aggressiveness. These results provide further support for the therapeutic targeting of translation in prostate cancer.
Authors
- Shreya Agarwal (ORCID: https://orcid.org/0000-0002-5926-7063)
- Kevin Z. Chen (ORCID: https://orcid.org/0000-0003-4250-8518)
- Apurv Rege (ORCID: https://orcid.org/0009-0007-8337-7100)
- Carolina Gomes Alexandre
- Qizhi Zheng
- Charles J. Bieberich (ORCID: https://orcid.org/0000-0002-9208-5077)
- Jessica Hicks (ORCID: https://orcid.org/0000-0001-7885-3319)
- Tracy Jones (ORCID: https://orcid.org/0009-0002-2882-4274)
- Angelo M. De Marzo (ORCID: https://orcid.org/0000-0003-4847-5307)
- Srinivasan Yegnasubramanian (ORCID: https://orcid.org/0000-0003-0744-6606)
- Michael Rubenstein (ORCID: https://orcid.org/0009-0004-4382-9342)
- Gretchen Hubbard
- Aidee Estrada
- Danielle Cannady
Institutions
- University of Maryland, Baltimore (US)
- University of Maryland Medical Center (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Caris Life Sciences (United States) (US)
- University of Maryland, Baltimore County (US)
Publication Details
- Journal
- Molecular Cancer Research
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1158/1541-7786.mcr-24-1206
- Citations
- 1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52