Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

The predominant cause of death among diabetic patients comes from cardiovascular complications, including vascular calcification. The objectives of this study were to improve the understanding of the molecular mechanisms involved in diabetes-related calcification and to test potential preventive therapies. We found that levels of plasma pyrophosphate-a potent inhibitor of calcification-were decreased in type 1 and type 2 diabetic patients with cardiovascular symptoms. To further investigate vascular calcification, we developed a diabetic mouse model that showed increased aorta and renal calcification compared to control. Alkaline phosphatase activity was also increased in the circulation of diabetic mice, which resulted in a significant decrease in plasma pyrophosphate. Oral treatment with pyrophosphate prevented diabetes-induced calcification in mice, providing a direct translational value for clinical applications.

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Journal
FEBS Open Bio
Published
2025-10-13
DOI
https://doi.org/10.1002/2211-5463.70141
Primary Topic
Dermatological and Skeletal Disorders
Type
article
Field-Weighted Citation Impact
0.00

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article

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

Eszter Kozák, Ágnes Diószegi, Andrea Kelemen, Zsolt Rapi et al.
FEBS Open Bio
Dermatological and Skeletal Disorders
article

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

Eszter Kozák, Ágnes Diószegi, Andrea Kelemen, Zsolt Rapi, Viola Pomozi, Mariann Harangi, Natália Tőkési, József Balla, László Kocsis, Krisztina Fülöp, András Váradi, Olivier Le Saux, Zsuzsanna Geszti, Adriána Kutás
article en

Abstract

The predominant cause of death among diabetic patients comes from cardiovascular complications, including vascular calcification. The objectives of this study were to improve the understanding of the molecular mechanisms involved in diabetes-related calcification and to test potential preventive therapies. We found that levels of plasma pyrophosphate-a potent inhibitor of calcification-were decreased in type 1 and type 2 diabetic patients with cardiovascular symptoms. To further investigate vascular calcification, we developed a diabetic mouse model that showed increased aorta and renal calcification compared to control. Alkaline phosphatase activity was also increased in the circulation of diabetic mice, which resulted in a significant decrease in plasma pyrophosphate. Oral treatment with pyrophosphate prevented diabetes-induced calcification in mice, providing a direct translational value for clinical applications.

FEBS Open BioVol. 16(3)
University of Hawaiʻi at Mānoa (US), University of Debrecen (HU), Budapest University of Technology and Economics (HU), HUN-REN Research Centre for Natural Sciences (HU)
Queen's University, Hungarian Scientific Research Fund, Magyar Tudományos Akadémia, Debreceni Egyetem, National Institutes of Health, National Research, Development and Innovation Office
Openalex Percentile: Top 69%
Dermatological and Skeletal Disorders
DOIOpen Access PDFOpenAlex
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