Neutrophil‐calibrated atypical squamous cells in ThinPrep urine cytology for detecting squamous differentiation in urothelial carcinoma
Neutrophil-calibrated ASC classification provides an objective, biologically grounded framework that aligns cytology with histology in UCSD. Reporting ASC-S/L-particularly ASC-S in equivocal (AUC) specimens-may facilitate earlier recognition of squamous differentiation and inform subsequent tissue evaluation. Prospective, multi-institutional validation with interobserver agreement and receiver operating characteristic-based thresholds is warranted.
Authors
- Ayako Furuhata
- Hironori Haga (ORCID: https://orcid.org/0000-0003-4322-9561)
- Yuki Teramoto (ORCID: https://orcid.org/0000-0002-8620-0710)
- Sachiko Minamiguchi (ORCID: https://orcid.org/0000-0002-5800-6769)
- Masahiro Hirata (ORCID: https://orcid.org/0000-0001-9211-0511)
Institutions
- Fujita Health University (JP)
- Kyoto University Hospital (JP)
Publication Details
- Journal
- Cancer Cytopathology
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1002/cncy.70055
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00