When Should Elective Neck Dissection Be Considered for Early‐Stage Oral Cavity Tumors? Insights From a Multicenter Study of 1109 Patients and Development of a Multiparametric Predictive Model

This study highlights the importance of incorporating multiple histopathological parameters into risk models for occult nodal metastases, overcoming the fixed DOI as a cutoff. The proposed predictive model offers a more precise method for guiding END in early-stage OCSCC, allowing individualized risk estimation.

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Publication Details

Journal
Head & Neck
Published
2025-10-13
DOI
https://doi.org/10.1002/hed.70064
Primary Topic
Head and Neck Cancer Studies
Type
article
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article

When Should Elective Neck Dissection Be Considered for Early‐Stage Oral Cavity Tumors? Insights From a Multicenter Study of 1109 Patients and Development of a Multiparametric Predictive Model

Alessandra Sordi, Gerardo Petruzzi, Alberto Deganello, Salvatore Poma et al.
Head & Neck
Head and Neck Cancer Studies
article

When Should Elective Neck Dissection Be Considered for Early‐Stage Oral Cavity Tumors? Insights From a Multicenter Study of 1109 Patients and Development of a Multiparametric Predictive Model

Alessandra Sordi, Gerardo Petruzzi, Alberto Deganello, Salvatore Poma, Milena Fior, Vincenzo Saita, Marco Radici, Cesare Piazza, Maurizio Pinamonti, Mario Turri–Zanoni, Sara Bassani, Stefano Pelucchi, Domenico Cuda, Daniele Spada, Maria Silvia Lazio, Giancarlo Tirelli, Matteo Fermi, Andrea Iandelli, Pietro De Luca, Alberto Vito Marcuzzo, Enrico Fazio, Virginia Corazzi, Matteo Garotta, Marco Ferrari, Paola Stritoni, Guido Bertolini, Paolo Castelnuovo, Guglielmo Ronzani, Ilaria Girolami, Daniele Marchioni, Rita De Berardinis, Riccardo Nocini, Mario Bussi, Luca Sacchetto, Simone Mauramati, Monir Abousiam, Fabiola Incandela, Francesco Mazzola, Davide Mattavelli, Andrea Galli, Alessandra Ruaro, Elisa Castelluccio, Rossana Bussani, Martina Renna, Cecilia Albi, Mohssen Ansarin, Anna Lisa Tosi, Elisa Laura, Luca de Campora, Angelo Camaioni, Giorgio Peretti, Darío Gregori, Pierre Guarino, Alberto Grammatica, Marta Tagliabue, Filippo Marchi, Valerio Arietti, G. Maruccio, Melania Franco, Andrea Sacchetto, Giandomenico Maggiore, Pasquale D’Alessio, Leone Giordano, Alessia Rubini, Antonio Sarno, Luca Gazzini, Giulia Togo, Doriano Politi, Domenico Michele Modica, Franco Ionna, Francesco Mattioli, Raul Pellini, Marco Benazzo, Gabriele Molteni, Bianca Maria Festa, Daria Salsi, Remo Accorona, Davide Di Santo, Chiara Bianchini, Mario Ciniglio Appiani, Roberto Saetti, Livio Presutti, M Ducci, Angela Gasparini, Virginia Dallari, Andy Bertolin, Francesco Uderzo, Gloria Brigiari, Carlotta Borghini, Francesca Angioletti, Fabrizio Russo, Luca Calabrese, M. C. Galfano, Alberto Giulio Dragonetti, Claudio Donadio Caporale, Roberto Di Carlo, Piero Nicolai, Giulia Gobbo
article en

Abstract

This study highlights the importance of incorporating multiple histopathological parameters into risk models for occult nodal metastases, overcoming the fixed DOI as a cutoff. The proposed predictive model offers a more precise method for guiding END in early-stage OCSCC, allowing individualized risk estimation.

Head & NeckVol. 48(3)
University of Bergamo (IT), Humanitas University (IT), University of Padua (IT), Vita-Salute San Raffaele University (IT), University of Ferrara (IT), Azienda Ospedaliera San Giovanni Addolorata (IT), Agostino Gemelli University Polyclinic (IT), Ospedale Santa Chiara (IT), Ospedale di Bolzano (IT), Ospedale "Santa Maria delle Croci" di Ravenna (IT), Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda (IT), Azienda Ospedaliera Universitaria Integrata Verona (IT), AULSS 2 Marca Trevigiana (IT), Ospedale Vincenzo Cervello (IT), Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT), Azienda Unità Sanitaria Locale Piacenza (IT), Ospedale di Santo Spirito (IT), Azienda Ospedaliero-Universitaria di Modena (IT), Azienda Ospedaliero-Universitaria Careggi (IT), Azienda USL di Bologna (IT), National Cancer Institute (UA), Ospedale di Circolo di Busto Arsizio (IT), National Cancer Institute (MY), Ospedale Sandro Pertini (IT), Ospedale Cannizzaro (IT), Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" (IT), Ospedale dell' Angelo (IT), European Society of Concurrent Enterprising Network (IT), Ca' Foncello Hospital (IT), Ospedale Policlinico San Martino (IT), Ospedale Santa Maria della Misericordia di Rovigo (IT), Ospedale Sant'Anna (IT), Policlinico San Matteo Fondazione (IT), Ospedale San Bortolo (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), Azienda Usl Toscana Centro (IT), Ospedale Civile di Vittorio Veneto (IT), IRCCS Humanitas Research Hospital (IT), Azienda Sanitaria Universitaria Integrata di Trieste (IT), Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT), European Institute of Oncology (IT), University of Bologna (IT), KU Leuven (BE)
Openalex Percentile: Top 62%
Head and Neck Cancer Studies
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