Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion

This study indicates that prolonged WI damage diminishes the contractility of VSMCs through the α-adrenergic receptors. Our findings suggest that the renal vascular responses to dopamine and norepinephrine, as well as decreased oxygen consumption and blood pH, could serve as objective indicators to quantify warm ischemic injury during renal NMP.

Authors

Henri G. D. Leuvenink (ORCID: https://orcid.org/0000-0001-5036-2999)
Isa M. Van Tricht (ORCID: https://orcid.org/0000-0002-8706-0908)
Cyril Moers (ORCID: https://orcid.org/0000-0001-8014-8387)
Baran Ogurlu (ORCID: https://orcid.org/0000-0001-5658-6838)
Silke S. M. Wolfswinkel

Institutions

University Medical Center Groningen (NL)

Publication Details

Journal: Artificial Organs
Published: 2025-10-13
DOI: https://doi.org/10.1111/aor.70033
Primary Topic: Organ Transplantation Techniques and Outcomes
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Nierstichting

Controls

|||

ALL TIME

JAN

FEB

MAR

APR

MAY

JUN

JUL

AUG

SEP

OCT

article

Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion

Henri G. D. Leuvenink, Isa M. Van Tricht, Cyril Moers, Baran Ogurlu et al.

Oct 13, 2025

Artificial Organs

Organ Transplantation Techniques and Outcomes

article

Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion

Henri G. D. Leuvenink, Isa M. Van Tricht, Cyril Moers, Baran Ogurlu, Silke S. M. Wolfswinkel

October 13, 2025article en

Abstract

This study indicates that prolonged WI damage diminishes the contractility of VSMCs through the α-adrenergic receptors. Our findings suggest that the renal vascular responses to dopamine and norepinephrine, as well as decreased oxygen consumption and blood pH, could serve as objective indicators to quantify warm ischemic injury during renal NMP.

Artificial OrgansVol. 50(2)

University Medical Center Groningen (NL)

Nierstichting

Openalex Percentile: Top 55%

Organ Transplantation Techniques and Outcomes

DOI Open Access PDF OpenAlex

AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.

Vasoreactivity as a Measure of Kidney Viability During Ex Vivo Normothermic Machine Perfusion — Henri G. D. Leuvenink, Isa M. Van Tricht, et al. · Artificial Organs (2025) | TGRS Research Map | TGRS