Dietary Nitrate Prevents Cardiac Dysfunction in <scp>HFrEF</scp> by Improving Hemodynamics, Ameliorating Remodeling, and Resolving Inflammation
Early initiation of dietary nitrate supplementation after myocardial injury enhances cardiac and vascular function, reduces fibrosis and inflammation, and holds promise as a cardioprotective strategy to reduce the progression of HFrEF through NO-signaling.
Authors
- Drielle D. Guimarães (ORCID: https://orcid.org/0000-0003-0510-2738)
- Jon O. Lundberg (ORCID: https://orcid.org/0000-0002-0174-5210)
- Miho Shimari
- Zhengbing Zhuge (ORCID: https://orcid.org/0000-0002-6002-6670)
- Mattias Carlström (ORCID: https://orcid.org/0000-0001-9923-8729)
- Giulia Picozzi (ORCID: https://orcid.org/0000-0003-2363-3807)
- Daniel Andersson (ORCID: https://orcid.org/0000-0003-4548-702X)
- Lars H. Lund (ORCID: https://orcid.org/0000-0003-1411-4482)
- Gianluigi Pironti (ORCID: https://orcid.org/0000-0001-9401-3029)
- Ariela Maína Boeder (ORCID: https://orcid.org/0000-0003-1991-7575)
Institutions
- Karolinska University Hospital (SE)
- Stockholm University (SE)
- Karolinska Institutet (SE)
- Wenner-Gren Foundations (SE)
Publication Details
- Journal
- Acta Physiologica
- Published
- 2025-10-13
- DOI
- https://doi.org/10.1111/apha.70115
- Citations
- 1
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Hjärt-Lungfonden
- Karolinska Institutet
- Knut och Alice Wallenbergs Stiftelse
- Stockholms Läns Landsting
- Vetenskapsrådet
- Ekhagastiftelsen