Trial‐Based Hemolysis Modeling to Investigate Operating Modes of Continuous‐Flow LVADs

The proposed hemolysis model allows to assess various LVAD operating modes and patient conditions, assisting in the selection of low-hemolysis treatment strategies. For Sputnik1 patients, it is advisable to maintain low pump speed and systemic resistance, while speed modulation should be reserved for those with low hemolysis markers. Integrating this model with online flow sensing would enable online hemolysis prediction.

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Publication Details

Journal
Artificial Organs
Published
2025-10-13
DOI
https://doi.org/10.1111/aor.70021
Primary Topic
Mechanical Circulatory Support Devices
Type
article
Field-Weighted Citation Impact
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article

Trial‐Based Hemolysis Modeling to Investigate Operating Modes of Continuous‐Flow LVADs

Steffen Leonhardt, Patrick Borchers, Marian Walter
Artificial Organs
Mechanical Circulatory Support Devices
article

Trial‐Based Hemolysis Modeling to Investigate Operating Modes of Continuous‐Flow LVADs

Steffen Leonhardt, Patrick Borchers, Marian Walter
article en

Abstract

The proposed hemolysis model allows to assess various LVAD operating modes and patient conditions, assisting in the selection of low-hemolysis treatment strategies. For Sputnik1 patients, it is advisable to maintain low pump speed and systemic resistance, while speed modulation should be reserved for those with low hemolysis markers. Integrating this model with online flow sensing would enable online hemolysis prediction.

Artificial OrgansVol. 50(2)
RWTH Aachen University (DE)
Openalex Percentile: Top 72%
Mechanical Circulatory Support Devices
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